In a video posted on social media, Kildee said for most of this year he was actively planning a campaign to run for Congress.
"But after spending time with my wife, my children, my grandchildren, contemplating our future, the time has come for me to step back from public office."
Kildee said a cancer diagnosis earlier this year was the catalyst behind rethinking his future in Congress. He's been cancer free ever since having a successful surgery.
According to the latest Cook Political Report, Michigan's eighth congressional district, which includes Midland, Bay City, Saginaw and Flint, a Republican candidate has a slim advantage in the district.
But Kildee said he's confident a Democrat will fill his open seat. His term in Congress ends on January 3, 2025.